Acid Ceramidase-IN-1( —— )

Catalog No. M35177 CAS No. 2415225-30-6

Acid Ceramidase-IN-1 is a highly effective, orally bioavailable inhibitor of acid ceramidase (AC, ASAH-1) with an IC50 of 0.166 μM and exhibits exceptional brain penetration capabilities in mice.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Biological Information

Product Name

Acid Ceramidase-IN-1
Note

Research use only, not for human use.
Brief Description

Acid Ceramidase-IN-1 is a highly effective, orally bioavailable inhibitor of acid ceramidase (AC, ASAH-1) with an IC50 of 0.166 μM and exhibits exceptional brain penetration capabilities in mice.
Description

Acid Ceramidase-IN-1 is a potent and oral bioavailable acid ceramidase (AC, ASAH-1) inhibitor (hAC IC50=0.166 μM). Acid Ceramidase-IN-1 has excellent brain penetration in mice.
In Vitro

——
In Vivo

——
Synonyms

——
Pathway

Others
Target

Other Targets
Recptor

Others
Research Area

——
Indication

——

Chemical Information

CAS Number

2415225-30-6
Formula Weight

331.41
Molecular Formula

C18H25N3O3
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (150.87 mM; Ultrasonic (<60°C)
SMILES

CC(C)CNC(=O)n1c2ccc(cc2oc1=O)C1CCN(C)CC1
Chemical Name

——

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Di Martino S, et al. Lead Optimization of Benzoxazolone Carboxamides as Orally Bioavailable and CNS Penetrant Acid Ceramidase Inhibitors. J Med Chem. 2020;63(7):3634-3664. ?

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